NEWS

David Sánchez-Infantes, Professor and researcher at the Department of Basic Health Sciences of the URJC, leads the work “Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome”

Posted by McG

The study of the lipidome of the newborn could contribute to predicting the risk of developing metabolic alterations in adulthood

 

The article has been published in the journal Nutrients, which has an impact factor of 6.7 according to JCR.

The study has been co-led by Dr. Lourdes Ibáñez (Department of Endocrinology, Sant Joan de Déu Research Institute, Barcelona), an expert in the study of metabolic and endocrine disorders in childhood with gestational and postnatal influence.

The work has been carried out in collaboration with Dr. Coral Barbas (Center for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo-CEU), which directed the lipidomic analysis carried out in the CEMBIO laboratory by Dr. Carolina González-Riano (first author of the article).

An untargeted lipidomics was performed to determine differences in umbilical cord blood lipid species between small (SGA), large (LGA), and adequate (AGA) for gestational age neonates. At CEMBIO, they identified for the first time differential patterns of cord blood lipidome in SGA, LGA and AGA.

In addition, some clearly modulated lipid species in each group were associated with parameters related to growth and glucose homeostasis, results obtained at the Hospital Sant Joan de Déu by Dr. Carles Lerin and the predoctoral researcher Marcelo Santos.

The researchers conclude that the specific lipidomic patterns observed in SGA, AGA and LGA newborns may influence adipose tissue remodeling and the appearance of metabolic alterations in childhood and adulthood. Maternal dietary interventions could provide long-term benefits for offspring metabolic health.

Reference:

https://www.mdpi.com/2072-6643/14/18/3760

 

Last modified on Tuesday, September 20, 2022 at 15:31